A recent review in *Nano-Micro Letters* examined the rapid progress of intelligent soft wearable systems enabled by advances in flexible materials, soft electronics, and artificial intelligence (AI). The authors emphasize how stretchable functional materials, energy-efficient device architectures, and AI-driven data analysis are driving progress toward more capable wearable technologies. The review presents an integrated perspective on the design of next-generation wearable platforms, outlining key opportunities and challenges for application in personalized healthcare, human-machine interaction, soft robotics, and digital medicine. Maintaining reliable long-term performance remains a major challenge, as mechanical deformation, body movement, sweat, and changing environmental conditions can disrupt the electrical interface between the device and the skin. The review highlights a shift toward cross-layer co-design, where researchers optimize materials, device architecture, energy efficiency, and machine learning as an integrated system. Advanced materials, including intrinsically stretchable conductors, conducting polymers, liquid metals, and nanowires, form the foundation of intelligent wearable systems by influencing sensing performance, mechanical durability, and user comfort.