On Sept. 18, 2026, Week 3 of college football features several key Big 12 matchups with playoff implications, with picks generated by an AI using 100 simulations for each game. A ranked matchup between No. 22 Houston and No. 13 Texas Tech kicks off the week on Friday, a game that will create an opening for the Big 12 title race and the College Football Playoff; a Houston win will make the Cougars a team to watch for a spot in the 12-team field. Other notable games include No. 17 Utah facing Utah State and No. 11 BYU playing Colorado State. The picks, made by ChatGPT using 100 simulations, include average scores and simulation records based on BetMGM point spreads and totals. The closest game is Colorado at Northwestern, with the Wildcats coming out on top 52 times with an average score of 24.2 to 23.8.