Amalgam Rx, Inc. has been named the winner of the “Overall Large Language Model of the Year” award in the ninth annual AI Breakthrough Awards program, recognizing its proprietary foundation model for predictive patient intelligence, Chiron, as the most impactful large language model in the global AI industry. The award was announced by AI Breakthrough, a market intelligence organization. This year’s program drew more than 5,000 nominations from leading AI companies across more than 20 countries. Driven by their Medical-Grade AI™, Amalgam’s Chiron is an autoregressive transformer trained on millions of longitudinal, de-identified patient records to predict the next medical event across therapeutic areas. In sleep apnea alone, Chiron delivered nearly a 2x improvement in diagnostic efficiency compared to traditional tools, identifying the same number of high-risk patients while reducing unnecessary diagnostic follow-ups by nearly half. Amalgam’s Chiron is designed to be embedded in EHR workflows across major health systems.