At Microsoft, Python is one of its most popular programming languages, with at least 67,000 employees using it daily. Python dependencies have emerged as a significant source of risk, representing the third-largest vulnerability surface across the company. While tools continuously detect and surface these risks, turning insights into action required a complex remediation process, as updating a single code package often caused changes across multiple interdependent libraries. To address this, Microsoft Digital developed an AI-powered solution called Python Dependency Remediation, which analyzes dependency chains, applies required updates, and automatically adjusts the code within the developer workflow. This enables engineers to remediate vulnerabilities quickly and consistently at enterprise scale. The tool has shown so much promise that Microsoft has begun releasing it externally for millions of Python developers worldwide.